Integrating tumor microenvironment with cancer molecular classifications
نویسندگان
چکیده
منابع مشابه
Molecular characterization of the tumor microenvironment in breast cancer.
Here we describe the comprehensive gene expression profiles of each cell type composing normal breast tissue and in situ and invasive breast carcinomas using serial analysis of gene expression. Based on these data, we determined that extensive gene expression changes occur in all cell types during cancer progression and that a significant fraction of altered genes encode secreted proteins and r...
متن کاملMolecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the "Warburg effect", commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial ...
متن کاملThe Tumor Microenvironment and Cancer
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis. Therefore, the characterization of these interactions, and the molecular identification of key mediators, will provide insights ...
متن کاملTumor microenvironment in cancer progression
Keywords: tumor microenvironment; Heat-shock Factor 1 (HSF1) Billions of years of evolution through changing environments led organisms to develop an arsenal of cytoprotec-tive pathways to promote their survival under stressful conditions. We hypothesized that tumors exploit these mechanisms to support their own survival as they rapidly develop and evolve in a hostile and stressful environment....
متن کاملSTAT3 as a Key Factor in Tumor Microenvironment and Cancer Stem Cell
Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Medicine
سال: 2015
ISSN: 1756-994X
DOI: 10.1186/s13073-015-0241-4